-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, VvDaQbikcmHkvkEQzrRh1ueyQRUCVYabfNe88BbZy+6Lsn3fYLMJ/SZjXbayD/9o /9L5mSPxoLyHHbQiiPghAA== 0000950005-02-000083.txt : 20020414 0000950005-02-000083.hdr.sgml : 20020414 ACCESSION NUMBER: 0000950005-02-000083 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20020201 GROUP MEMBERS: ALIX MARDUEL GROUP MEMBERS: ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC. GROUP MEMBERS: ALTA BIOPHARMA PARTNERS, L.P. GROUP MEMBERS: ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC GROUP MEMBERS: ALTA PARTNERS GROUP MEMBERS: ALTA/CHASE BIOPHARMA MANAGEMENT, LLC GROUP MEMBERS: DANIEL JANNEY GROUP MEMBERS: GARRETT GRUENER GROUP MEMBERS: GUY NOHRA GROUP MEMBERS: JEAN DELEAGE GROUP MEMBERS: THE MEDICINES COMPANY CHASE PARTNERS (ALTA BIO), LLC SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: MEDICINES CO/ MA CENTRAL INDEX KEY: 0001113481 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 043324394 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-60201 FILM NUMBER: 02525231 BUSINESS ADDRESS: STREET 1: ONE CAMBRIDGE CTR CITY: CAMBRIDGE STATE: MA ZIP: 02142 BUSINESS PHONE: 6172259099 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: ALTA PARTNERS CENTRAL INDEX KEY: 0001060013 IRS NUMBER: 943238854 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 BUSINESS PHONE: 4153624022 MAIL ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 SC 13G/A 1 p14884_sc13-ga.txt SCHEDULE 13G/A United States Securities and Exchange Commission WASHINGTON, D.C. 20549 Schedule 13G (Amendment No. _1_)* UNDER THE SECURITIES EXCHANGE ACT OF 1934 THE MEDICINES COMPANY (Name of Issuer) Common Stock (Title of Class of Securities) 58468810 (CUSIP Number) December 31, 2001 - -------------------------------------------------------------------------------- (Date of Event That Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: |_| Rule 13d-1(b) |X| Rule 13d-1(c) |_| Rule 13d-1(d) * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
CUSIP No. 58468810 Page 2 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Partners - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization California - ------------------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IA - ------------------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No.58468810 Page 3 of 16 Pages - ------------------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Partners, L.P. - ------------------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ------------------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person PN - -------------------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 4 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Management Partners, LLC. - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power 2,581,425 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 2,581,425 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - ----------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 5 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons The Medicines Company Chase Partners (Alta Bio), LLC - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - ----------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 6 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Embarcadero BioPharma Partners, LLC - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization California - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - ----------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 7 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta/Chase BioPharma Management, LLC - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization Delaware - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person CO - ----------------------------------------------------------------------------------------------------------
CUSIP No. 58468810 Page 8 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Jean Deleage - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ---------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 9 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Garrett Gruener - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ---------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 10 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Daniel Janney - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ---------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 11 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alix Marduel - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ---------------------------------------------------------------------------------------------------------- (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ---------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 58468810 Page 12 of 16 Pages - ---------------------------------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Guy Nohra - ---------------------------------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ---------------------------------------------------------------------------------------------------------- (3) SEC Use Only - ---------------------------------------------------------------------------------------------------------- (4) Citizenship or Place of Organization United States - ---------------------------------------------------------------------------------------------------------- Please see Attachment A Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 2,581,425 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 2,581,425 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 2,581,425 Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* (11) Percent Of Class Represented By Amount In Row (11) 7.4% Please see Attachment A - ---------------------------------------------------------------------------------------------------------- (12) Type Of Reporting Person IN - ---------------------------------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!
Item 1. (a) Name of Issuer: The Medicines Company ("Issuer") (b) Address of Issuer's Principal Executive Offices: One Cambridge Center Cambridge, MA 02142 Item 2. (a) Name of Person Filing: Alta Partners ("AP") Alta BioPharma Partners, L.P. ("ABP") Alta BioPharma Management Partners, LLC. ("ABMP") Alta Embarcadero BioPharma Partners, LLC ("AEBP") The Medicines Company Chase Partners (Alta Bio), LLC ("MCCP") Alta/Chase BioPharma Management, LLC ("ACMP") Jean Deleage ("JD") Garrett Gruener ("GG") Dan Janney ("DJ") Alix Marduel ("AM") Guy Nohra ("GN") (b) Address of Principal Business Office: One Embarcadero Center, Suite 4050 San Francisco, CA 94111 (c) Citizenship/Place of Organization: Entities: AP - California ABP - Delaware ABMP Delaware AEBP California MCCP Delaware ACMP Delaware Individuals: JD United States GG United States DJ United States AM United States GN United States (d) Title of Class of Securities: Common Stock (e) CUSIP Number: 58468810 (f) Item 3. Not applicable.
Item 4 Ownership. Please see Attachment A - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- AP ABP ABMP AEBP MCCP ACMP - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 7.4% 7.4% 7.4% 7.4% 7.4% 7.4% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- JD GG DJ AM GN - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 7.4% 7.4% 7.4% 7.4% 7.4% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power 2,581,425 2,581,425 2,581,425 2,581,425 2,581,425 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Item 5. Ownership of Five Percent or Less of a Class Not Applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person Not applicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group No reporting person is a member of a group as defined in Section 240.13d-1(b)(1)(ii)(H) of the Act. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification By signing below we certify that, to the best of our knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. EXHIBITS A: Joint Filing Statement Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: January 29, 2002 ALTA PARTNERS ALTA BIOPHARMA PARTNERS, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------------------------- ------------------------------------ Jean Deleage, President Alix Marduel, Managing Director ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ------------------------------------------------ ------------------------------------ Alix Marduel, Member Jean Deleage, Member THE MEDICINES COMPANYCHASE PARTNERS (ALTA BIO), LLC ALTA/CHASE BIOPHARMA MANAGEMENT, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ------------------------------------------------ ------------------------------------ Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra - --------------------------------------------------- --------------------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Alix Marduel - --------------------------------------------------- --------------------------------------------- Garrett Gruener Alix Marduel /s/ Daniel Janney - --------------------------------------------------- Daniel Janney
EXHIBIT A AGREEMENT OF JOINT FILING We, the undersigned, hereby express our agreement that the attached Schedule 13G is filed on behalf of us.
Date: January 29, 2002 ALTA PARTNERS ALTA BIOPHARMA PARTNERS, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------------------------- ----------------------------------------- Jean Deleage, President Alix Marduel, Managing Director ALTA BIOPHARMA MANAGEMENT PARTNERS, LLC ALTA EMBARCADERO BIOPHARMA PARTNERS, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ----------------------------------------- ----------------------------------------- Alix Marduel, Member Jean Deleage, Member THE MEDICINES COMPANYCHASE PARTNERS (ALTA BIO), LLC ALTA/CHASE BIOPHARMA MANAGEMENT, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ----------------------------------------- ----------------------------------------- Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra - -------------------------------------------- -------------------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Alix Marduel - -------------------------------------------- -------------------------------------------- Garrett Gruener Alix Marduel /s/ Daniel Janney - -------------------------------------------- Daniel Janney
Attachment A Alta Partners provides investment advisory services to several venture capital funds including Alta BioPharma Partners L.P., The Medicines Company Chase Partners (Alta Bio) LLC and Alta Embarcadero BioPharma Partners, LLC. Alta BioPharma Partners L.P. beneficially owns 1,425,594 shares of Common Stock and Warrants for 178,987 shares of Common Stock. The Medicines Company Chase Partners (Alta Bio) LLC beneficially owns 814,149 shares of Common Stock and Warrants for 102,218 shares of Common Stock. Alta Embarcadero BioPharma Partners, LLC beneficially owns 53,731 shares of Common Stock and Warrants for 6,746 shares of Common Stock. The respective general partners and managing members of Alta BioPharma Partners, L.P., The Medicines Company Chase Partners (Alta Bio) LLC and Alta Embarcadero BioPharma Partners, LLC exercise sole voting and investment power with respect to the shares owned by such funds. Certain Principals of Alta Partners are managing directors of Alta BioPharma Management Partners, LLC and Alta/Chase Management Partners LLC (the general partner of Alta BioPharma Partners L.P. and the managing members of The Medicines Company Chase Partners (Alta Bio) LLC respectively. As managing directors, they may be deemed to share voting and investment powers of the shares held by the fund. These principals disclaim beneficial ownership of all such funds held by the aforementioned fund, except to the extent of their proportionate pecuniary interests therein. Mr. Jean Deleage is a managing director of Alta BioPharma Management Partners, LLC (which is the general partner of Alta BioPharma Partners, L.P.), a managing director of Alta/Chase Management Partners LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC) and a member of Alta Embarcadero BioPharma Partners, LLC. Thus he shares voting and dispositive powers of over the 1,425,594 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P.; the 814,149 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC; and the 53,731 share of Common Stock and the Warrants for 6,746 shares of Common Stock beneficially owned by Alta Embarcadero BioPharma Partners, LLC. Mr. Deleage disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein. Mr. Garrett Gruener is a managing director of Alta BioPharma Management Partners, LLC (which is the general partner of Alta BioPharma Partners, L.P.), a managing director of Alta/Chase Management Partners LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC) and a member of Alta Embarcadero BioPharma Partners, LLC. Thus he shares voting and dispositive powers of over the 1,425,594 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P.; the 814,149 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC; and the 53,731 share of Common Stock and the Warrants for 6,746 shares of Common Stock beneficially owned by Alta Embarcadero BioPharma Partners, LLC. Mr. Gruener disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein. Page 1 of 2 of Attachment A Page 2 of 2 of Attachment A Mr. Daniel Janney is a managing director of Alta BioPharma Management Partners, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and a managing director of Alta/Chase Management Partners LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC). Thus he shares voting and dispositive powers of over the 1,425,594 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P., and the 814,149 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC. Mr. Janney disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein. Dr. Alix Marduel is a managing director of Alta BioPharma Management Partners, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and a managing director of Alta/Chase Management Partners LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC). Thus he shares voting and dispositive powers of over the 1,425,594 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P., and the 814,149 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC. Dr. Marduel disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of her proportionate pecuniary interests therein. Mr. Guy Nohra is a managing director of Alta BioPharma Management Partners, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and a managing director of Alta/Chase Management Partners LLC (which is the managing member of The Medicines Company Chase Partners (Alta Bio), LLC). Thus he shares voting and dispositive powers of over the 1,425,594 shares of Common Stock and the Warrants for 178,987 shares of Common Stock beneficially owed by Alta BioPharma Partners, L.P., and the 814,149 shares of Common Stock and the Warrants for 102,218 shares of Common Stock beneficially owned by The Medicines Company Chase Partners (Alta Bio), LLC. Mr. Nohra disclaims beneficial ownership of the shares held by the aforementioned funds except to the extent of his proportionate pecuniary interests therein Alta Partners is a venture capital company with an office in San Francisco. Alta Partners is California Corporation. Alta BioPharma Partners, L.P. is a Delaware Limited Partnership, The Medicines Company Chase Partners (Alta Bio), LLC is a Delaware Limited Liability Company, and Alta Embarcadero BioPharma Partners, LLC is a California Limited Liability Company.
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