FORM 4

[__] Check this box if no longer
subject to Section 16. Form 4 or Form
5 obligations may continue.
See Instruction 1(b).

(Print or Type Responses)
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility
Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person*
   Stack, David M

(Last)                      (First)                      (Middle)

  c/o The Medicines Company
     5 Sylvan Way

(Street)

  Parsippany, NJ 07054

(City)                      (State)                      (Zip)

2. Issuer Name and Ticker
    or Trading Symbol

   The Medicines Company - MDCO

3. I.R.S. Identification
    Number of Reporting
    Person, if an entity
    (voluntary)

     
4. Statement for
    (Month/Day/Year)

   12/02/2002


5. If Amendment,
    Date of Original
    (Month/Day/Year)

    
6. Relationship of Reporting Person(s) to Issuer
(Check all applicable)


   X    Director                                __   10% Owner

   X    Officer (give title below)        __   Other (specify below)

    President and Chief Executive Officer    

7. Individual or Joint/Group Filing (Check Applicable Line)

  _ X    Form filed by One Reporting Person

  ____    Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security
    (Instr. 3)

2. Transaction Date
    (Month/Day/Year)
2A. Deemed Execution       Date, if any
      (Month/Day/Year)
3. Transaction Code
    (Instr. 8)
4. Securities Acquired (A) or
    Disposed of (D)
    (Instr. 3, 4, and 5)
5. Amount of
    Securities
    Beneficially
    Owned
    Following     Reported     Transaction(s)
    (Instr. 3 and 4)
6. Ownership Form:
    Direct (D) or
    Indirect (I)
    (Instr. 4)
7. Nature of Indirect Beneficial
    Ownership
    (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock12/02/2002 M 7000A3.08   
Common Stock (1)12/02/2002 S 3000D16.60   
Common Stock (1)12/02/2002 S 1000D16.62   
Common Stock (1)12/02/2002 S 600D16.63   
Common Stock (1)12/02/2002 S 90D16.65   
Common Stock (1)12/02/2002 S 2310D16.615000D 

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
    (Instr. 3)
2. Conver-
    sion or
    Exercise
    Price of
    Deri-
    vative
    Security
3. Transaction
    Date  (Month/
    Day/ Year)
3A. Deemed
      Execution Date,
      if any (Month/
      Day/ Year)
4. Transaction Code     
    (Instr.8)

5. Number of
   
Derivative
    Securities Acquired
    (A)
    or Disposed of (D)
    (Instr. 3, 4 and 5)

6. Date Exercisable and
    Expiration Date
    (Month/Day/Year)
7. Title and Amount
    of  Underlying
    Securities
    (Instr. 3 and 4)
8. Price of
    Derivative
    Security
    (Instr. 5)
9. Number of
    Derivative
    Securities
    Beneficially
    Owned
    Following
    Reported
    Transaction(s)
    (Instr. 4)
10. Ownership
     Form of      Derivative
     Securities:
     Direct (D)
     or
     Indirect (I)
     (Instr. 4)
11. Nature of
      Indirect
      Beneficial
      Ownership
      (Instr. 4)
Code V (A) (D) Date
Exercisable
Expiration
Date
Title Amount or
Number of
Shares
Stock Option (Right to Buy)3.0812/02/2002 M  7000 (2) 04/01/2010Common Stock7000 51700D 

Explanation of Responses:  (1) The common stock sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 program adopted by Mr. Stack on November 21, 2002.
     (2) As of 12-02-2002, the option (originally granted 4-1-2000) was vested with respect to 47906 of the shares covered thereby. After the exercises of the options reported hereby, as of 12-02-2002, 33906 of the shares covered by the option were vested and the remaining 17794 shares covered by the option vest in equal monthly installments ending 1-1-2004.


            /s/ David M. Stack                     12/03/2002   
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations.
        See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note:   File three copies of this Form, one of which must be manually signed. If space is insufficient,
            See Instruction 6 for procedure.